Peer Reviewed

1

Document Type

Article

Publication Date

21-3-2011

Keywords

Platelets, Immune System, Bacteria

Comments

This is the pre-peer reviewed version of the following article: Cox D, Kerrigan SW, Watson SP. Platelets and the innate immune system: Mechanisms of bacterial-induced platelet activation. J Thromb Haemost. 2011 Mar 21, which has been published in final form at http://onlinelibrary.wiley.com/

Abstract

It has become clear that platelets are not simply cell fragments that can plug the leak in a damaged blood vessel, they are in fact key components in the innate immune system which is supported by the presence of Toll-like receptors (TLRs) on platelets. As the first responding cell to a site of injury they are well placed to direct the immune response to deal with any resulting exposure to pathogens. The response is triggered by bacteria binding to platelets which usually triggers platelet activation and the secretion of anti-microbial peptides. The main platelet receptors that mediate these interactions are GPIIb/IIIa, GPIbα, FcνRIIa, complement receptors and TLRs. This may involve direct interactions between bacterial proteins and the receptors or can be mediated by plasma proteins such as fibrinogen, von Willebrand factor, complement and IgG. Here we review the variety of interactions between platelets and bacteria and look at the potential for inhibiting these interactions in diseases such as infective endocarditis and sepsis.

Disciplines

Life Sciences

Citation

Cox D, Kerrigan SW, Watson SP. Platelets and the innate immune system: Mechanisms of bacterial-induced platelet activation. J Thromb Haemost. 2011 Mar 21.

PubMed ID

21435167

DOI Link

10.1111/j.1538-7836.2011.04264.x

Included in

Life Sciences Commons

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