Document Type

Article

Publication Date

6-1-2008

Keywords

Amino Acid Sequence, Animals, Antiviral Agents, Humans, Interferon Regulatory Factors, Molecular Sequence Data, Ubiquitin, Ubiquitination

Comments

This article is also available at http://www.biochemsoctrans.org/bst/036/0453/bst0360453.htm

Abstract

The IRF [IFN (interferon) regulatory factor] family of transcription factors control many cellular processes, including induction of key antiviral cytokines, type I IFNs, following viral infection. Recent studies have revealed several endogenous and viral proteins involved in ubiquitin-mediated regulation of IRF activity and thus having an impact on type I IFN signalling. Through the ubiquitin pathway, these proteins can manipulate the antiviral response either by initiating proteasomal degradation of the IRFs or, in contrast, by promoting activation of the IRFs.

Disciplines

Life Sciences

Citation

Higgs R, Jefferies CA. Targeting IRFs by ubiquitination: regulating antiviral responses. Biochemical Society Transactions 2008;36(3):453-8.

PubMed ID

18481980

DOI Link

10.1042/BST0360453


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