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Submissions from 2013

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The Role of Platelets in Viral Hemorrhagic Fevers, Dermot Cox, Maria S. Salvato, and Juan Carlos Zapata

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MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1., Laura Creevey, Jacqueline Ryan, Harry Harvey, Isabella M. Bray, Maria Meehan, Adnan R. Khan, and Raymond L. Stallings

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Increased platelet counts and platelet activation in early symptomatic versus asymptomatic carotid stenosis and relationship with microembolic status: Results from the Platelets And Carotid Stenosis (PACS) Study, J A. Kinsella, W O. Tobin, S Tierney, T M. Feeley, B Egan, D R. Collins, T Coughlan, D O'Neill, J Harbison, P Madhavan, D J. Moore, S M. O'Neill, M P. Coughlan, C P. Doherty, R P. Murphy, M Saqqur, Niamh Moran, G Hamilton, and D JH McCabe

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A novel platinum complex of the histone deacetylase inhibitor belinostat: rational design, development and in vitro cytotoxicity., James P. Parker, Hassan Nimir, Darren M. Griffith, Brian Duff, Anthony J. Chubb, Marian P. Brennan, Maria Morgan, Denise Egan, and Celine Marmion

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Pregnancy-Specific Glycoproteins Bind Integrin αIIbβ3 and Inhibit the Platelet-Fibrinogen Interaction., Daniel K. Shanley, Patrick K. Kiely, Kalyan Golla, Seamus Allen, Kenneth Martin, Ronan T. O'Riordan, Melanie Ball, John D. Aplin, Bernhard B. Singer, Noel Caplice, Niamh Moran, and Tom Moore

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Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases., Arthur Smardencas, Kerelos Rizkalla, Hyun Ah Kim, Jim Massalas, Claire O'Leary, Michelle E. Ehrlich, Günter Schütz, Andrew J. Lawrence, and John Drago

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Expressional alterations in functional ultra-conserved non-coding rnas in response to all-trans retinoic acid - induced differentiation in neuroblastoma cells., Karen M. Watters, Kenneth Bryan, Niamh H. Foley, Maria Meehan, and Raymond L. Stallings

Submissions from 2012

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Chronic Adolescent Exposure to Delta-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Indices of Dopaminergic, Endocannabinoid and GABAergic Pathways., Aine T. Behan, Magdalena Hryniewiecka, Colm MP O'Tuathaigh, Anthony Kinsella, Mary Cannon, Maria Karayiorgou, Joseph A. Gogos, John L. Waddington, and David R. Cotter

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Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers., Anneleen Decock, Maté Ongenaert, Jasmien Hoebeeck, Katleen De Preter, Gert Van Peer, Wim Van Criekinge, Ruth Ladenstein, Johannes H. Schulte, Rosa Noguera, Raymond L. Stallings, An Van Damme, Geneviève Laureys, Joëlle Vermeulen, Tom Van Maerken, Frank Speleman, and Jo Vandesompele

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Platelet-Bacterial Interactions as Therapeutic Targets in Infective Endocarditis, Steven W. Kerrigan and Dermot Cox

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Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis., Ross C. McKiernan, Eva M. Jimenez-Mateos, Isabella Bray, Tobias Engel, Gary P. Brennan, Takanori Sano, Zuzanna Michalak, Catherine Moran, Norman Delanty, Michael Farrell, Donncha O'Brien, Robert Meller, Roger P. Simon, Raymond L. Stallings, and David C. Henshall

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Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene., Maria Meehan, Laavanya Parthasarathi, Niamh Moran, Caroline A. Jefferies, Niamh Foley, Elisa Lazzari, Derek Murphy, Jacqueline Ryan, Berenice Ortiz, Armida WM Fabius, Timothy A. Chan, and Raymond L. Stallings

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Differential DNA methylation patterns define status epilepticus and epileptic tolerance., Suzanne F C Miller-Delaney, Sudipto Das, Takanori Sano, Eva M. Jimenez-Mateos, Kenneth Bryan, Patrick G. Buckley, Raymond L. Stallings, and David C. Henshall

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Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase., Erika Salvi, Zoltán Kutalik, Nicola Glorioso, Paola Benaglio, Francesca Frau, Tatiana Kuznetsova, Hisatomi Arima, Clive Hoggart, Jean Tichet, Yury P. Nikitin, Costanza Conti, Jitka Seidlerova, Valérie Tikhonoff, Katarzyna Stolarz-Skrzypek, Toby Johnson, Nabila Devos, Laura Zagato, Simonetta Guarrera, Roberta Zaninello, Andrea Calabria, Benedetta Stancanelli, Chiara Troffa, Lutgarde Thijs, Federica Rizzi, Galina Simonova, Sara Lupoli, Giuseppe Argiolas, Daniele Braga, Maria C. D'Alessio, Maria F. Ortu, Fulvio Ricceri, Maurizio Mercurio, Patrick Descombes, Maurizio Marconi, John Chalmers, Stephen Harrap, Jan Filipovsky, Murielle Bochud, Licia Iacoviello, Justine Ellis, Alice V. Stanton, Maris Laan, Sandosh Padmanabhan, Anna F. Dominiczak, Nilesh J. Samani, Olle Melander, Xavier Jeunemaitre, Paolo Manunta, Amnon Shabo, Paolo Vineis, Francesco P. Cappuccio, Mark J. Caulfield, Giuseppe Matullo, Carlo Rivolta, Patricia B. Munroe, Cristina Barlassina, Jan A. Staessen, Jacques S Beckmann, and Daniele Cusi

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Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity., Kevin B. Stacey, Eamon Breen, and Caroline A. Jefferies

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Barriers to the uptake of evidence from systematic reviews and meta-analyses: a systematic review of decision makers' perceptions., John Wallace, Bosah Nwosu, and Mike Clarke

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Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis., Amro Widaa, Tania Claro, Timothy J. Foster, Fergal J. O'Brien, and Steven W. Kerrigan

Submissions from 2011

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Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis., Tania Claro, Amro Widaa, Maghnus O'Seaghdha, Helen Miajlovic, Timothy J. Foster, Fergal J. O'Brien, and Steven W. Kerrigan

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Platelets and the innate immune system: Mechanisms of bacterial-induced platelet activation., Dermot Cox, Steven W. Kerrigan, and Steve Watson

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Convulsant doses of a dopamine D1 receptor agonist result in Erk-dependent increases in Zif268 and Arc/Arg3.1 expression in mouse dentate gyrus., Giuseppe Gangarossa, Manuela Di Benedetto, Gerard J. O'Sullivan, Mark Dunleavy, Cristina Alcacer, Alessandra Bonito-Oliva, David C. Henshall, John L. Waddington, Emmanuel Valjent, and Gilberto Fisone

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Simultaneous release of a hydroxy-methylglutaryl coenzyme A reductase inhibitor and a glycoprotein IIb/IIIa antagonist from a thermoresponsive NiPAAm/NtBAAm copolymer system., Jennifer A. Hickey, I Lynch, Kenneth A. Dawson, Dermot Cox, and A K. Keenan

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Platelet signalling networks: pathways perturbation demonstrates differential sensitivity of ADP secretion and fibinogen binding., Federica Lombardi, Ciaran De Chaumont, Denis C. Shields, and Niamh Moran

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HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans., Mark McCormack, Ana Alfirevic, Stephane Bourgeois, John J. Farrell, Dalia Kasperavičiūtė, Mary Carrington, Graeme J. Sills, Tony Marson, Xiaoming Jia, Paul IW de Bakker, Krishna Chinthapalli, Mariam Molokhia, Michael R. Johnson, Gerard D. O'Connor, Elijah Chaila, Saud Alhusaini, Kevin V. Shianna, Rodney A. Radtke, Erin L. Heinzen, Nicole Walley, Massimo Pandolfo, Werner Pichler, B Kevin Park, Chantal Depondt, Sanjay M. Sisodiya, David B. Goldstein, Panos Deloukas, Norman Delanty, Gianpiero L. Cavalleri, and Munir Pirmohamed

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Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology., Annette E. Rünker, Colm O'Tuathaigh, Mark Dunleavy, Derek W. Morris, Graham E. Little, Aiden P. Corvin, Michael Gill, David C. Henshall, John L. Waddington, and Kevin J. Mitchell

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A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: the MORGAM project., Ciara Vangjeli, Patrick Dicker, David-Alexandre Tregouet, Denis C. Shields, Alun Evans, and Alice V. Stanton

Submissions from 2010

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TNF Receptor-Associated Factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets., J F. Arthur, Y Shen, E E. Gardiner, Lorraine Coleman, Dermot Kenny, R K. Andrews, and Michael C. Berndt

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Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders, Cynthia M. Beall, Gianpiero L. Cavalleri, Libin Deng, Robert C. Elston, Yang Gao, Jo Knight, Chaohua Li, Jiang Chuan Li, Yu Liang, Mark McCormack, Hugh E. Montgomery, Hao Pan, Peter A. Robbins, Kevin V. Shianna, Siu Cheung Tam, Ngodup Tsering, Krishna Veeramah, Wei Wang, Puchung Wangdui, Michael E. Weale, Yaomin Xu, Zhe Xu, Ling Yang, M Justin Zaman, Changqing Zeng, Li Zhang, Xianglong Zhang, Pingcuo Zhaxi, and Yong Tang Zheng

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Integrins as therapeutic targets: lessons and opportunities., Dermot Cox, Marian P. Brennan, and Niamh Moran

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Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors., Rowan Higgs, Elisa Lazzari, Claire Wynne, Joan Ní Gabhann, Alexander Espinosa, Marie Wahren-Herlenius, and Caroline A. Jefferies

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Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer, Gregor Kijanka, Suzanne Hector, Elaine W. Kay, Frank E. Murray, Robert Cummins, Derek Murphy, B MacCraith, Jochen HM Prehn, and Dermot Kenny

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The meniscus, calcification and osteoarthritis: a pathologic team., Paul A. MacMullan and Geraldine M. McCarthy

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Clopidogrel discontinuation and platelet reactivity following coronary stenting., Darren Mylotte, Aaron Peace, Tony Tedesco, Fabio Mangiacapra, Patrick Dicker, Dermot Kenny, and David Foley

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Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function., Soumya Raychaudhuri, Joshua M. Korn, Steven A A. McCarroll, The International Schizophrenia Consortium, David Altshuler, Pamela Sklar, Shaun Purcell, and Mark J. Daly

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Prevalence and clinical correlates of depression in the acute phase of first episode schizophrenia, Eric Roche, Mary Clarke, Stephen Browne, Niall Turner, Orflaith McTuige, Moaayad Kamali, Anthony Kinsella, Conall Larkin, John L. Waddington, and Eadbhard O'Callaghan

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Genome wide association study of nonsynonymous Single Nucleotide Polymorphisms for seven common diseases, Praveen Surendran, Alice Stanton, and Denis Shields

Submissions from 2009

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Continuous positive airway pressure and platelet activation in obstructive sleep apnoea., Dermot Cox and Aidan Bradford

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Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer., Glen A. Doherty, Sinead M. Byrne, Eamonn S. Molloy, Vikrum Malhotra, Sandra C. Austin, Elaine Kay, Frank E. Murray, and Desmond J. Fitzgerald

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Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway., Alexander Espinosa, Valerie Dardalhon, Susanna Brauner, Aurelie Ambrosi, Rowan Higgs, Fransisco J. Quintana, Maria Sjöstrand, Maija-Leena Eloranta, Joan Ní Gabhann, Ola Winqvist, Birgitta Sundelin, Caroline A. Jefferies, Björn Rozell, Vijay K. Kuchroo, and Marie Wahren-Herlenius

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A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity., Darren Griffith, Maria P. Morgan, and Celine J. Marmion

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cDNA amplification by SMART-PCR and suppression subtractive hybridization (SSH)-PCR., Andrew Hillmann, Eimear Dunne, and Dermot Kenny

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Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer., Anthony J. Ryan, Silvia Napoletano, Paul A. Fitzpatrick, Caroline A. Currid, Niamh C. O'Sullivan, and Judith H. Harmey

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Genomes2Drugs: identifies target proteins and lead drugs from proteome data, David Toomey, Heinrich C. Hoppe, Marian P. Brennan, Kevin B. Nolan, and Anthony J. Chubb

Submissions from 2008

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C-reactive protein binds to alphaIIbbeta3., Marian P. Brennan, Roisin D. Moriarty, S Grennan, Anthony J. Chubb, and Dermot Cox

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Targeting IRFs by ubiquitination: regulating antiviral responses., Rowan Higgs and Caroline A. Jefferies

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Molecular basis for Staphylococcus aureus-mediated platelet aggregate formation under arterial shear in vitro., Steven W. Kerrigan, Niamh Clarke, Anthony Loughman, Gerardene Meade, Timothy J. Foster, and Dermot Cox

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Marked variation in predicted and observed variability of tandem repeat loci across the human genome., Colm T. O'Dushlaine and Denis C. Shields

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Aldosterone-mediated apical targeting of ENaC subunits is blunted in rats with streptozotocin-induced diabetes mellitus., Heidi O'Neill, Janne Lebeck, Patrick B. Collins, Tae-Hwan Kwon, Jørgen Frøkiaer, and Søren Nielsen

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Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling., Gerard J. O'Sullivan, Mark Dunleavy, Kerstin Hakansson, Mario Clementi, Anthony Kinsella, David T. Croke, John Drago, Allen A. Fienberg, Paul Greengard, David R. Sibley, Gilberto Fisone, David C. Henshall, and John L. Waddington

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Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1., Colm M. O'Tuathaigh, Anne-Marie O'Connor, Gerard J. O'Sullivan, Donna Lai, Richard Harvey, David T. Croke, and John L. Waddington

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Dual antiplatelet therapy unmasks distinct platelet reactivity in patients with coronary artery disease., Aaron Peace, Tony Tedesco, David Foley, Patrick Dicker, Michael Berndt, and Dermot Kenny

Submissions from 2007

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Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice., Daniela Babovic, Colm M. O'Tuathaigh, Gerard J. O'Sullivan, Jeremiah J. Clifford, Orna Tighe, David T. Croke, Maria Karayiorgou, Joseph A. Gogos, David Cotter, and John L. Waddington

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Three-dimensional laser surface imaging and geometric morphometrics resolve frontonasal dysmorphology in schizophrenia., Robin J. Hennessy, Patrizia A. Baldwin, David J. Browne, Anthony Kinsella, and John L. Waddington

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Both complement- and fibrinogen-dependent mechanisms contribute to platelet aggregation mediated by Staphylococcus aureus clumping factor B., Helen Miajlovic, Anthony Loughman, Marian P. Brennan, Dermot Cox, and Timothy J. Foster

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Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1., Colm M. O'Tuathaigh, Daniela Babovic, Gerard J. O'Sullivan, Jeremiah J. Clifford, Orna Tighe, David T. Croke, R Harvey, and John L. Waddington

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Impaired glucose tolerance in first-episode drug-naïve patients with schizophrenia., L M. Spelman, P I. Walsh, N Sharifi, Patrick B. Collins, and J H. Thakore

Submissions from 2006

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Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers., Dermot Cox, Andrew O. Maree, Michelle Dooley, Ronán Conroy, Michael F. Byrne, and Desmond J. Fitzgerald

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The interaction of bacterial pathogens with platelets., J Ross Fitzgerald, Timothy J. Foster, and Dermot Cox

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Tools for the identification of variable and potentially variable tandem repeats., Colm T. O'Dushlaine and Denis C. Shields

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Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions., Maghnus O'Seaghdha, Carina J. van Schooten, Steven W. Kerrigan, Jonas Emsley, Gregg J. Silverman, Dermot Cox, Peter J. Lenting, and Timothy J. Foster

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Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout', Katsunori Tomiyama, Yasuyuki Makihara, Hiroshi Yamamoto, Gerard J. O'Sullivan, Rachel E. Nally, Orna Tighe, Anthony Kinsella, Allen A. Fienberg, David K. Grandy, David R. Sibley, David T. Croke, Noriaki Koshikawa, and John L. Waddington

Submissions from 2005

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Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians., Ciara Dolan, Denis C. Shields, Alice Stanton, Eoin O'Brien, Deborah M. Lambert, John K. O'Brien, and Eileen P. Treacy

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Tyrosine phosphorylation of myosin heavy chain during skeletal muscle differentiation: an integrated bioinformatics approach., Donal F. Harney, Ryan K. Butler, and Richard J. Edwards

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Facial surface analysis by 3D laser scanning and geometric morphometrics in relation to sexual dimorphism in cerebral--craniofacial morphogenesis and cognitive function., Robin J. Hennessy, Stephen McLearie, Anthony Kinsella, and John L. Waddington

Submissions from 2004

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Elevated white cell count in acute coronary syndromes: relationship to variants in inflammatory and thrombotic genes., Connie E. Byrne, Anthony Fitzgerald, Christopher P. Cannon, Desmond J. Fitzgerald, and Denis C. Shields

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GASP: Gapped Ancestral Sequence Prediction for proteins., Richard J. Edwards and Denis C. Shields

Submissions from 2003

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In silico proteome analysis to facilitate proteomics experiments using mass spectrometry., Gerard Cagney, Shiva Amiri, Thanuja Premawaradena, Micheal Lindo, and Andrew Emili

Submissions from 2001

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Inflammatory microcrystals induce murine macrophage survival and DNA synthesis., John A. Hamilton, Geraldine McCarthy, and G Whitty