Peer Reviewed

1

Document Type

Article

Publication Date

26-3-2015

Keywords

Prescribing, Medication use, Pregnancy, FDA pregnancy-risk categories

Funder/Sponsor

Health Research Board of Ireland, Charitable Infirmary Charitable Trust, Association of Physicians of Great Britain & Ireland, the Madeleine Farrell Bequest, Alumni Office Yacob Kadwa General Practice Research Award.

Comments

The original article is available at www.biomedcentral.com

Abstract

BACKGROUND: To establish the prevalence and patterns of prescribing to pregnant women in an Irish primary care setting.

METHODS: We reviewed electronic healthcare records routinely collected in primary care, of pregnant women attending nine Dublin-based General Practices affiliated to the Irish Primary Care Research Network (IPCRN) for antenatal care between January 2007 and October 2013 (n = 2,361 pregnancies).

RESULTS: Excluding folic acid, 46.8% (n = 1,104) of pregnant women were prescribed at least one medication. Amoxicillin (11.1%, n = 263) and co-amoxiclav (8.0%, n = 190) were the most commonly prescribed medication followed by topical clotrimazole (4.9%, n = 117), salbutamol inhalers (4.1%, n = 96) and paracetamol (4.0%, n = 95). General Medical Services (GMS) patients were more likely to receive a prescription than private patients (OR 2.81; 95%CI (2.28, 3.47)). We applied the US FDA pregnancy-risk categories as a proxy measure of prescribing appropriateness, with FDA Category D and X medications considered inappropriate. FDA Category D drugs were prescribed in 5.9% (n = 140) of pregnancies. FDA Category X drugs were prescribed in 4.9% (n = 116) of pregnancies but after exclusion of oral contraceptives, progestogens, infertility treatments Category X medications were prescribed in 0.6% (n = 13) of pregnancies. After the initial antenatal consultation the prescribing prevalence of FDA Category D medications reduced to 4.7% (n = 110) and Category X to 3.1% (n = 72).

CONCLUSIONS: The overall prevalence of prescribing to pregnant women in our cohort is low compared to studies internationally, however similar levels of prescribing for FDA Category D and X were found. Following the initial antenatal consultation levels of prescribing of the FDA Category D and X medications reduced, however there is potential to further reduce their use in early pregnancy. The IPCRN database has provided valuable information on the current practice of antenatal prescribing within this pilot group of practices however it is limited by the absence of morbidity and pregnancy outcome data.

Disciplines

Medicine and Health Sciences

Citation

Dillon P, O'Brien KK, McDonnell R, Donnelly-Swift E, Galvin R5, Roche A, Cronin K, Walsh DR, Schelten R, Smith S, Fahey T. Prevalence of prescribing in pregnancy using the Irish primary care research network: a pilot study. BMC Pregnancy and Childbirth 2015;15:67

PubMed ID

25884886

DOI Link

10.1186/s12884-015-0489-0

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