Document Type

Article

Publication Date

2013

Keywords

Animals, Endothelial Cells, Hindlimb, Ischemia, Male

Comments

The original article is available at www.biomedcentral.com

Abstract

Murine models of hind-limb ischemia are frequently used to assess interventions aimed at improving therapeutic angiogenesis in critical limb ischemia. Much of the current focus of angiogenesis lies with mesenchymal stem cells (MSCs). Important considerations when using these models include the strain of mouse, because some strains recover from ischemia more rapidly than others, and the MSC source. MSCs derived from certain strains generate increased levels of growth factors such as vascular endothelial growth factor. This may significantly affect the limb?s ability to generate collateral vessels.

Disciplines

Anatomy

Citation

Duffy GP, Herron CC. Mesenchymal stem cells to augment therapeutic angiogenesis in hind-limb ischemia models: how important is their source? Stem Cell Research & Therapy. 2013;4(5):131.

PubMed ID

24156359

DOI Link

10.1186/scrt342

Creative Commons License


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