Peer Reviewed

1

Document Type

Article

Publication Date

3-6-2015

Keywords

Articular cartilage, collagen-based scaffolds, growth factor delivery, mesenchymal stem cells, transforming growth factor-beta 3

Funder/Sponsor

Enterprise Ireland, Commercialization Fund Technology

Comments

The original article is available at onlinelibrary.wiley.com

Abstract

Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen-hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.

Disciplines

Anatomy

Citation

Matsiko A, Levingstone TJ, Gleeson JP, O'Brien FJ. Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential. Advanced Healthcare Materials. 2015;4(8):1175-9.

PubMed ID

25800862

DOI Link

10.1002/adhm.201500053

Creative Commons License


This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

Included in

Anatomy Commons

Share

COinS