Peer Reviewed

1

Document Type

Article

Publication Date

28-1-2015

Keywords

Gene-activated scaffolds, non-viral gene therapy, mesenchymal stem cells, bone regeneration, collagen scaffolds

Funder/Sponsor

European Research Council. Science Foundation Ireland

Comments

The original article is available at http://onlinelibrary.wiley.com

Abstract

Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering both an angiogenic and an osteogenic gene. Stem cell-mediated osteogenesis in vitro, in addition to increased vascularization and bone repair by host cells in vivo, is enhanced using all systems while the use of the nanohydroxyapatite vector to deliver both genes markedly enhances bone healing.

Disciplines

Anatomy

Citation

Curtin CM, Tierney EG, McSorley K, Cryan SA, Duffy GP, O'Brien FJ. Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold. Advanced Healthcare Materials. 2015;4(2):223-7

PubMed ID

25125073

DOI Link

10.1002/adhm.201400397

Creative Commons License


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