Peer Reviewed

1

Document Type

Article

Publication Date

1-1-2013

Keywords

Tissue Engineering, Bone, Regeneration, Scaffold, Cell-Scaffold Interactions

Comments

This article is available with the kind permission of full reproduction from eCM journal (www.ecmjournal.org). Founded by scientists for the benefit of Science rather than profit.

Link to, http://www.ecmjournal.org/journal/papers/vol026/vol026a09.php

Abstract

Bone tissue engineering has emerged as one of the leading fields in tissue engineering and regenerative medicine. The success of bone tissue engineering relies on understanding the interplay between progenitor cells, regulatory signals, and the biomaterials/scaffolds used to deliver them--otherwise known as the tissue engineering triad. This review will discuss the roles of these fundamental components with a specific focus on the interaction between cell behaviour and scaffold structural properties. In terms of scaffold architecture, recent work has shown that pore size can affect both cell attachment and cellular invasion. Moreover, different materials can exert different biomechanical forces, which can profoundly affect cellular differentiation and migration in a cell type specific manner. Understanding these interactions will be critical for enhancing the progress of bone tissue engineering towards clinical applications.

Disciplines

Anatomy

Citation

Murphy CM, O'Brien FJ, Little DG, Schindeler A. Cell-scaffold interactions in the bone tissue engineering triad. European Cells and Materials. 2013;26:120-132.

PubMed ID

24052425

Included in

Anatomy Commons

Share

COinS