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Submissions from 2014

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Comparison of performance in a four year graduate entry medical programme and a traditional five/six year programme., Annette T. Byrne, Richard Arnett, Tom Farrell, and Seamus Sreenan

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Fatigue failure of osteocyte cellular processes: implications for the repair of bone., Clodagh Dooley, Daniel Cafferky, T Clive Lee, and David Taylor

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Enamel matrix derivative has no effect on the chondrogenic differentiation of mesenchymal stem cells, Lisanne C. Groeneveldt, Callie Knuth, Janneke Witte-Bourna, Fergal O'Brien, Eppo B. Wolvius, and Eric Farrell

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A biomimetic multi-layered collagen-based scaffold for osteochondral repair., Tanya J. Levingstone, Amos Matsiko, Glenn R Dickson, Fergal J. O'Brien, and John P. Gleeson

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The osteogenic potential of the marine-derived multi-mineral formula aquamin is enhanced by the presence of vitamin D., Amro Widaa, Orlaith Brennan, D M. O'Gorman, and Fergal J. O'Brien

Submissions from 2013

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Examination of osteoarthritis and subchondral bone alterations within the stifle joint of an ovariectomised ovine model., Jane C. Holland, Orlaith Brennan, O D. Kennedy, N J. Mahony, S Rackard, Fergal O'Brien, and T Clive Lee

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Subchondral osteopenia and accelerated bone remodelling post-ovariectomy - a possible mechanism for subchondral microfractures in the aetiology of spontaneous osteonecrosis of the knee?, Jane C. Holland, Orlaith Brennan, Oran D. Kennedy, Susan M. Rackard, Fergal O'Brien, and T Clive Lee

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Advanced Strategies for Articular Cartilage Defect Repair, Amos Matsiko, Tanya J. Levingstone, and Fergal O'Brien

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Cell-scaffold interactions in the bone tissue engineering triad., Ciara M. Murphy, Fergal J. O'Brien, David G. Little, and Aaron Schindeler

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Chitosan for gene delivery and orthopedic tissue engineering applications., Rosanne Raftery, Fergal O'Brien, and Sally-Ann Cryan

Submissions from 2012

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Temporal changes in bone composition, architecture, and strength following estrogen deficiency in osteoporosis., Orlaith Brennan, Julia S. Kuliwaba, T Clive Lee, Ian H. Parkinson, Nicola L. Fazzalari, Laoise M. McNamara, and Fergal J. O'Brien

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Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro., Orlaith Brennan, Fergal J. O'Brien, and Laoise M. McNamara

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Influence of flow rate and scaffold pore size on cell behavior during mechanical stimulation in a flow perfusion bioreactor., Ryan J. McCoy, C Jungreuthmayer, and Fergal O'Brien

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Visualising feasible operating ranges within tissue engineering systems using a "windows of operation" approach: A perfusion-scaffold bioreactor case study., Ryan J. McCoy and Fergal J. O'Brien

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Distribution of microcrack lengths in bone in vivo and in vitro., Gerardo Presbitero, Fergal O'Brien, T Clive Lee, and David Taylor

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Mechanical characterization of a customized decellularized scaffold for vascular tissue engineering., W S. Sheridan, Garry P. Duffy, and B P. Murphy

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Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis., Amro Widaa, Tania Claro, Timothy J. Foster, Fergal J. O'Brien, and Steven W. Kerrigan

Submissions from 2011

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Evaluation of the ability of collagen-glycosaminoglycan scaffolds with or without mesenchymal stem cells to heal bone defects in Wistar rats., Mohamed Alhag, E Farrell, M Toner, T Clive Lee, Fergal J. O'Brien, and N Claffey

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The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis., Orlaith Brennan, Oran D. Kennedy, T Clive Lee, Susan M. Rackard, Fergal J. O'Brien, and Laoise M. McNamara

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Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis., Tania Claro, Amro Widaa, Maghnus O'Seaghdha, Helen Miajlovic, Timothy J. Foster, Fergal J. O'Brien, and Steven W. Kerrigan

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In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells., Eric Farrell, Sanne K. Both, Kathrin I. Odörfer, Wendy Koevoet, Nicole Kops, Fergal J. O'Brien, Robert J Baatenburg de Jong, Jan A. Verhaar, Vincent Cuijpers, John Jansen, Reinhold G. Erben, and Gerjo JVM van Osch

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Temporal and spatial changes in cartilage-matrix-specific gene expression in mesenchymal stem cells in response to dynamic compression., Matthew G. Haugh, Eric G. Meyer, Stephen D. Thorpe, Tatiana Vinardell, Garry P. Duffy, and Daniel J. Kelly

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Crosslinking and Mechanical Properties Significantly Influence Cell Attachment, Proliferation, and Migration Within Collagen Glycosaminoglycan Scaffolds., Matthew G. Haugh, Ciara M. Murphy, Ross C. McKiernan, Cornelia Altenbuchner, and Fergal J. O'Brien

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Subchondral trabecular structural changes in the proximal tibia in an ovine model of increased bone turnover., Jane C. Holland, Orlaith Brennan, Oran D. Kennedy, Susan M. Rackard, Fergal J. O'Brien, and T Clive Lee

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3 hours of perfusion culture prior to 28 days of static culture, enhances osteogenesis by human cells in a collagen GAG scaffold., Michael B. Keogh, Sonia Partap, Jacqueline Daly, and Fergal J. O'Brien

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Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering., Amos Matsiko, Tanya Levingstone, Fergal J. O'Brien, and John P. Gleeson

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Biomaterials and scaffolds for tissue engineering, Fergal J. O'Brien

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The Marine-derived, Multi-mineral formula, Aquamin, Enhances Mineralisation of Osteoblast Cells In Vitro., Denise M O'Gorman, Claire M. Tierney, Orlaith Brennan, and Fergal J. O'Brien

Submissions from 2010

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Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis., Orlaith Brennan, Oran D. Kennedy, T Clive Lee, Susan M. Rackard, and Fergal J. O'Brien

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Development and characterisation of a collagen nano-hydroxyapatite composite scaffold for bone tissue engineering., Grainne M. Cunniffe, Glenn R. Dickson, Sonia Partap, Kenneth T. Stanton, and Fergal J. O'Brien

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The synthesis and characterization of nanophase hydroxyapatite using a novel dispersant-aided precipitation method., Grainne M. Cunniffe, Fergal J. O'Brien, Sonia Partap, Tanya J. Levingstone, Kenneth T. Stanton, and Glenn R. Dickson

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Novel freeze-drying methods to produce a range of collagen-glycosaminoglycan scaffolds with tailored mean pore sizes., Matthew G. Haugh, Ciara M. Murphy, and Fergal J. O'Brien

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Structural adaptation and intracortical bone turnover in an ovine model of osteoporosis., Claragh Healy, Oran D. Kennedy, Orlaith Brennan, Susan Rackard, Fergal J. O'Brien, and T Clive Lee

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A novel collagen scaffold supports human osteogenesis--applications for bone tissue engineering., Michael B. Keogh, Fergal J. O'Brien, and Jacqueline Daly

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Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness., Hanifeh Khayyeri, Sara Checa, Magnus Tägil, Fergal J. O'Brien, and Patrick J. Prendergast

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Influence of shear stress in perfusion bioreactor cultures for the development of three-dimensional bone tissue constructs: a review., Ryan J. McCoy and Fergal J. O'Brien

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The effect of mean pore size on cell attachment, proliferation and migration in collagen glycosaminoglycan scaffolds for tissue engineering., Ciara M. Murphy, Matthew G. Haugh, and Fergal J. O'Brien

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IV.3. Bioreactors in tissue engineering., Niamh A. Plunkett and Fergal J. O'Brien

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Osteoblast response to rest periods during bioreactor culture of collagen-glycosaminoglycan scaffolds., Niamh A. Plunkett, Sonia Partap, and Fergal J. O'Brien

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Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis., Adam JF Stops, N M. Harrison, Matthew G. Haugh, Fergal J. O'Brien, and P E. McHugh

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A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow., Adam JF Stops, K B. Heraty, M Browne, Fergal J. O'Brien, and P E. McHugh

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The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-beta3 induced chondrogenic differentiation., Stephen D. Thorpe, Conor T. Buckley, Tatiana Vinardell, Fergal J. O'Brien, Veronica A. Campbell, and Daniel J. Kelly

Submissions from 2009

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Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair., Amir A. Al-Munajjed and Fergal J. O'Brien

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Development of a biomimetic collagen-hydroxyapatite scaffold for bone tissue engineering using a SBF immersion technique., Amir A. Al-Munajjed, Niamh A. Plunkett, John P. Gleeson, Tim Weber, Christian Jungreuthmayer, Tanya Levingstone, Joachim Hammer, and Fergal J. O'Brien

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Biomechanical properties across trabeculae from the proximal femur of normal and ovariectomised sheep., Orlaith Brennan, Oran D. Kennedy, T Clive Lee, Susan M. Rackard, and Fergal J. O'Brien

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The effect of dehydrothermal treatment on the mechanical and structural properties of collagen-GAG scaffolds., Matthew G. Haugh, Michael J. Jaasma, and Fergal J. O'Brien

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Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model., Christian Jungreuthmayer, Michael J. Jaasma, Amir A. Al-Munajjed, J Zanghellini, Daniel J. Kelly, and Fergal J. O'Brien

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Stimulation of osteoblasts using rest periods during bioreactor culture on collagen-glycosaminoglycan scaffolds., Sonia Partap, Niamh A. Plunkett, Daniel J. Kelly, and Fergal J. O'Brien

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The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering., Claire M. Tierney, Matthew G. Haugh, Jakob Liedl, Fergal Mulcahy, Brian Hayes, and Fergal J. O'Brien

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Osteoblast activity on collagen-GAG scaffolds is affected by collagen and GAG concentrations., Claire M. Tierney, Michael J. Jaasma, and Fergal J. O'Brien

Submissions from 2008

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Development of a collagen calcium-phosphate scaffold as a novel bone graft substitute., Amir A. Al-Munajjed, John P. Gleeson, and Fergal J. O'Brien

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Gene expression by marrow stromal cells in a porous collagen-glycosaminoglycan scaffold is affected by pore size and mechanical stimulation., Elaine M. Byrne, Eric Farrell, Louise A. McMahon, Matthew G. Haugh, Fergal J. O'Brien, Veronica A. Campbell, Patrick J. Prendergast, and Brian C. O'Connell

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Biomechanical comparison of the pullout properties of external skeletal fixation pins in the tibiae of intact and ovariectomised ewes., Ben J. Keeley, Behnam Heidari, Nicholas J. Mahony, Susan M. Rackard, Fergal J. O'Brien, T Clive Lee, Orlaith Brennan, Oran D. Kennedy, and David FitzPatrick

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The effects of increased intracortical remodeling on microcrack behaviour in compact bone., Oran D. Kennedy, Orlaith Brennan, Peter Mauer, Susan M. Rackard, Fergal J. O'Brien, David Taylor, and T Clive Lee

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Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells., S D. Thorpe, C T. Buckley, T Vinardell, Fergal J. O'Brien, V A. Campbell, and Daniel J. Kelly

Submissions from 2007

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The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering., Fergal J. O'Brien, Brendan A A. Harley, Mary A A. Waller, Ioannis V V. Yannas, Lorna J. Gibson, and Patrick J. Prendergast

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Bone as a composite material: the role of osteons as barriers to crack growth in compact bone., Fergal J. O'Brien, David Taylor, and T Clive Lee

Submissions from 2005

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The effect of pore size on cell adhesion in collagen-GAG scaffolds., Fergal J. O'Brien, B A. Harley, Ioannis V. Yannas, and Lorna J. Gibson

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The effect of bone microstructure on the initiation and growth of microcracks., Fergal J. O'Brien, David Taylor, and T Clive Lee

Submissions from 2004

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Influence of freezing rate on pore structure in freeze-dried collagen-GAG scaffolds., Fergal J. O'Brien, Brendan A. Harley, Ioannis V. Yannas, and Lorna J. Gibson

Submissions from 2003

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Detecting microdamage in bone., T Clive Lee, Sahar Mohsin, David Taylor, Raman Parkesh, TThorfinnur Gunnlaugsson, Fergal J. O'Brien, Michael Giehl, and Wolfgang Gowin

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Microcrack accumulation at different intervals during fatigue testing of compact bone., Fergal J. O'Brien, David Taylor, and T Clive Lee

Submissions from 2002

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An improved labelling technique for monitoring microcrack growth in compact bone., Fergal J. O'Brien, David Taylor, and T Clive Lee

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A theoretical model for the simulation of microdamage, repair and adaptation in compact bone., David Taylor, Fergal J. O'Brien, and T Clive Lee

Submissions from 2000

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The nature of fatigue damage in bone, T Clive Lee, Fergal J. O'Brien, and David Taylor

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Visualisation of three-dimensional microcracks in compact bone., Fergal J. O'Brien, David Taylor, G R R. Dickson, and T Clive Lee